Resveratrol is a naturally occurring polyphenolic compound found largely in the skins of the grapes (Vitis vinifera) and the products prepared from it such as red-wine, however presence of resveratrol has been identified in several other plant species except grapes such as peanuts, berries and legumes.

Activation of sirtuins, a class of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases, modulation of cell cycle regulatory genes, activation of transcription factors and inhibition of protein kinases are some proposed mechanisms of action of resveratrol.
Molecular pathways involved in the beneficial effects of calorie restriction, exercise, and resveratrol on mitochondrial function and metabolic health. Phosphorylation and activation of AMPK upon reduced ATP levels (due to calorie restriction or exercise), or directly by resveratrol, triggers an increase in the cellular NAD+/NADH ratio, which activates sirtuin 1 (SIRT1).

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